Monitor Closely (one)mitotane decreases levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Mitotane can be a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for probable dosage changes.Drugs that could blunt the growth hormone (GH) response to macrimorelin might